Regioselective One-pot Transformation of 2’-Hydroxy Chalcones to 3,5-Diphenylisoxazole via Dehydrogenation of Dihydroisoxazolines Using Copper Salt in DMF

نویسندگان
Gaikwad, Milind V ID 1

1 Department of Chemistry, Dr. D Y Patil ACS College Pimpri, Savitribai Phule Pune University, Pune, India

doi
10.22034/jaoc.2021.278705.1010
چکیده

A synthesis of series of 3, 5-diaryl isoxazoles has been described. The Cu salt in DMF with EDU base induces oxidative dehydrogenation of 2-(5-phenyl-4,5-dihydroisoxazol-3-yl) phenol results in the formation of 2-(5-phenylisoxazol-3-yl) phenol in excellent yields under mild reaction conditions. The present protocol contains cheap catalyst, easy workup, normal reaction conditions and high selectivity.

کلیدواژه‌ها
dehydrogenation, Cu salt, 2’ -hydroxy chalcones, 3, 5-diphenylisoxazole, dihydroisoxazolines