Synthesis, Spectral and Biological Studies of DHA Schiff Bases

نویسندگان
Vithal Narte, Dnyaneshwar ID 1
Pradip Kale, Rushikesh ID 2
Momin, Kalimoddin Inayatsab ID 3
Palke, Dhananjay Gangadhar ID 4
Bhagwatrao Biradar, Shubham ID 5
Sudewad, Maroti Sayabu ID 6
Tayade, Kundan Chandramani ID 7

1 Department of Chemistry, Rajarshi Shahu Mahavidyalaya, (Autonomous) Latur (M. S.), India

2 Department of Chemistry, Rajarshi Shahu Mahavidyalaya, (Autonomous) Latur (M. S.), India

3 Department of Chemistry, Rajarshi Shahu Mahavidyalaya, (Autonomous) Latur (M. S.), India

4 Department of Chemistry, Rajarshi Shahu Mahavidyalaya, (Autonomous) Latur (M. S.), India

5 Department of Chemistry, Rajarshi Shahu Mahavidyalaya, (Autonomous) Latur (M. S.), India

6 Department of Chemistry, Rajarshi Shahu Mahavidyalaya, (Autonomous) Latur (M. S.), India

7 Department of Chemistry, Rajarshi Shahu Mahavidyalaya, (Autonomous) Latur (M. S.), India

doi
10.22034/jaoc.2021.275758.1003
چکیده

A new series of Schiff bases derived from DHA (Dehydroacetic acid) and aromatic primary amines were synthesized and characterized by elemental and spectral (Electronic, IR and 1HNMR) analysis. The signals of 1HNMR spectrum and characteristic peaks in IR spectra are used for the molecular structure elucidation of synthesized Schiff bases. The antimicrobial activities of synthesized compounds have been screened in vitro against Escherichia coli, Staphylococcus aureus, Bacillus subtilis bacterial species, Candida albicans and Aspergillus niger fungal organism and found to exhibit strong antifungal activity than antibacterial activity. Among the studied DHA Schiff base of 2-amino-4,6-dimethylpyrimidine depicted discerning antifungal and antibacterial activities.

کلیدواژه‌ها
Dehydroacetic acid, Schiff bases, Spectral and Biological study