فهرست نشریات علمی دسترسی آزاد ایران

This review highlights recent advances in ovarian organoid research. Ovarian organoids are three-dimensional (3D)structures derived from primary ovarian tissues, cancer cells, or stem cells that replicate key architectural and functionalfeatures of native ovarian tissue. Their formation requires both germ cells, such as oocytes and primordial germcells, and somatic cells, including stromal, thecal, follicular, and epithelial cells. Ovarian organoids are typicallycharacterized through histological, molecular, and functional analyses to confirm their structural and transcriptionalresemblance to the native ovary. These organoids contain a heterogeneous population of cell types, reflecting the cellulardiversity of ovarian tissue, and exhibit gene expression profiles closely aligned with those of primary ovariantissues. Organoids derived from both normal and malignant sources hold great potential for a wide range of applications,including basic ovarian biology, cancer research and therapeutics, fertility studies, drug screening, disease andcancer modeling, endocrine function studies, personalized medicine, and pathogen interaction analysis. Despite existingtechnical and biological challenges, ongoing research and innovations continue to expand the potential of ovarianorganoids in reproductive biology and disease management.