فهرست نشریات علمی دسترسی آزاد ایران

Background: Polycystic ovary syndrome (PCOS) may extend to cognitive impairments. This preclinical and experimentalstudy investigates the physiological effects of PCOS on neurogenesis and cognitive function, emphasizing thepotential benefits of lifestyle modifications and complementary and alternative medicine (CAM) interventions. Theproposed study covers the synergistic effects of swimming and soybean supplementation on genetic networks (mRNA-lncRNAs) in the context of inflammation, oxidative stress, and cognitive impairment corresponding to PCOS.Materials and Methods: In this bioinformatic and experimental study, the mice were categorized into five groups:the control, the polycystic group [mice were orally administered 0.5 mg/kg of letrozole for 6 weeks then received 45%high-fat diet (HFD) for 12 weeks], the polycystic group with swimming training (swimming for 5 days a week for 8weeks), the polycystic group with soy supplement consumption (150 mg/kg), the polycystic group that received bothswimming exercise and soy supplement intake. Gene expression was quantified using the real-time polymerase chainreaction (PCR) approach. mRNAs and lncRNAs were identified as potential diagnostic or prognostic biomarkers usinga bioinformatics approach. Computational modeling technique is used to predict small molecules’ binding affinityand orientation to a target protein.Results: Swimming exercise combined with soy isoflavone supplementation improved cognitive outcomes and neurogenesisin PCOS mice through upregulation of neurogenesis-related genes and restoration of hormonal balance,suggesting potential therapeutic benefits for PCOS-associated cognitive dysfunction. The observed increases in theexpression of neurogenesis-related genes and improvements in hormonal balance suggest that these interventions maymitigate some of the cognitive impairments associated with PCOS.Conclusion: The findings suggest that complementary and alternative medicine approaches offer therapeutic benefitsfor symptom mitigation and systemic health improvement in PCOS management.