فهرست نشریات علمی دسترسی آزاد ایران

Background: Recurrent implantation failure (RIF) is a challenging condition affecting approximately 10% ofin vitro fertilization (IVF) patients. Despite extensive investigations, up to half of cases remain unexplained. Immunedysregulation has been implicated in RIF, and intravenous immunoglobulin (IVIg) therapy has emerged as a potentialtreatment. However, the efficacy of IVIg for unexplained RIF remains controversial due to inconsistent study designsand outcomes. The aim of this study was to evaluate the impact of IVIg on pregnancy and live birth rates in womenwith unexplained RIF.Materials and Methods: A retrospective cohort study was conducted on 136 women with unexplained RIF undergoingfrozen embryo transfer (FET) at Yazd Reproductive Sciences Research Institute and Reproductive MedicineDepartment of Madar Hospital, Yazd, Iran between April 2019 and March 2024. The study included women withunexplained RIF who underwent FET following endometrial preparation using hormonal therapy and received at leastthree doses of IVIg therapy. Baseline characteristics and pregnancy outcomes were compared.Results: A total of 68 patients were included in each group. The IVIg group had a significantly higher biochemical pregnancyrate compared to the control group [26(38.2%) vs. 13(19.1%), P=0.014]. Although clinical pregnancy, ongoing pregnancy,and live birth rates were numerically higher in the IVIg group, these differences did not reach statistical significance.Conclusion: Our findings suggest that IVIg treatment may be associated with higher biochemical pregnancy womenwith unexplained RIF. However, larger prospective studies are needed to confirm these results and to assess the longtermeffects of IVIg on pregnancy outcomes.