Association of Interleukin-33 with Recurrent Pregnancy Loss: A Systematic Review and Meta-Analysis Study
نویسندگان
1 Shahid AkbarAbadi Clinical Research Development Unit (SHACRDU), School of Medicine, Iran University of Medical Sciences, Tehran, Iran
2 Department of Health Education, School of Medicine, Tarbiat Modares University, Tehran, Iran
3 School of Medicine, Iran University of Medical Sciences, Tehran, Iran
4 Firoozabadi Clinical Research Development Unit (FACRDU), Iran University of Medical Sciences, Tehran, Iran
5 Department of Obstetrics and Gynecology, Social Determinants of Health, Research Center, School of Medical Sciences, Alborz University of Medical Sciences, Karaj, Iran
doi
10.22074/ijfs.2025.2035863.1733چکیده
Background: Recurrent pregnancy loss (RPL) is a condition in which a woman experiences two or more consecutivemiscarriages before reaching 20 weeks of gestation. The present study was designed to explore the potential linkbetween the interleukin (IL)-33 and RPL. To achieve this goal, we conducted a comprehensive search across the ISI,PubMed, Embase, and Scopus databases.Materials and Methods: We reviewed studies that examined the relationship between specific IL-33 polymorphismsand RPL using the appropriate keywords. The comparator in our study consisted of a control group that includedwomen without RPL. This group was used to assess the differences in genetic polymorphisms and IL-33 serum levelscompared to women who experienced RPL. We analyzed the collected data using a random-effects model in STATA(version 14). Five case-control studies were eligible, yielding a total sample size of 1,831 participants (891 cases and940 controls).Results: The results revealed a significant association between the GG genotype of IL-33 polymorphisms rs16924159and rs1929992 [odds ratio (OR)=0.72, 95% confidence intervals (CI)=0.51-1.02, I2=58.2, P=0.068] and RPL. Thepresence of the GG genotype of IL-33 polymorphisms rs16924159 and rs1929992 in women was associated with a0.72-fold increased risk of RPL. Additionally, no statistically significant correlation was noted between IL-33 GA(OR=1.19, 95% CI=75-1.88, I2=80.7, P=0.001) and AA (OR=1.02, 95% CI=0.81-1.29, I2=71.8, P=0.029) genotypesand RPL. Analysis of IL-33 serum levels indicated a significant association with RPL (OR=-0.45, 95% CI=-0.67-(-0.23), I2=57.3, P=0.128).Conclusion: Our findings demonstrate an association between the GG genotype of IL-33 polymorphisms and an increasedrisk of RPL. Moreover, higher serum levels of IL-33 are likely protective against RPL.
