The Role of Nutrition in Endometriosis Prevention and Management: A Comprehensive Review
نویسندگان
1 Reproductive Immunoendocrinology Division, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia -dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia
2 Human Reproduction, Infertility, and Family Planning Cluster, Indonesia Reproductive Medicine Research and Training Center, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
3 Human Reproduction, Infertility, and Family Planning Cluster, Indonesia Reproductive Medicine Research and Training Center, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
4 Yasmin IVF Clinic dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia
5 Human Reproduction, Infertility, and Family Planning Cluster, Indonesia Reproductive Medicine Research and Training Center, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
6 Reproductive Immunoendocrinology Division, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia -dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia
7 Yasmin IVF Clinic dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia
8 Reproductive Immunoendocrinology Division, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia -dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia
9 Reproductive Immunoendocrinology Division, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia -dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia
10 Reproductive Immunoendocrinology Division, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia -dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia
doi
10.22074/ijfs.2025.2029021.1683چکیده
Endometriosis is a chronic gynecological condition defined by the ectopic presence of endometrial-like tissue outsidethe uterine cavity, often resulting in debilitating symptoms and significant impacts on quality of life. While the exactetiology of endometriosis remains elusive, emerging evidence suggests that diet and nutrition may play a crucial rolein its pathogenesis and management. This comprehensive review explores the complex interplay between variousfood substances and endometriosis, summarizing the latest research findings on both risk-enhancing and protectivenutritional factors. Notably, consumption of alcohol, red and processed meats, foods high in saturated and trans fats,and excessive caffeine has been correlated with increased systemic inflammation and hormonal dysregulation-keymechanisms implicated in endometriosis pathogenesis. In contrast, nutrients such as antioxidants, B-complex vitamins,vitamin D, calcium, polyunsaturated fatty acids (PUFAs, particularly omega-3 and omega-6), and dietary fiberhave shown promise in exerting anti-inflammatory and protective effects against endometriosis. The review emphasizesthe importance of promoting a balanced and nutritious diet rich in anti-inflammatory and antioxidant-rich foodwhile limiting the intake of pro-inflammatory substances for individuals with endometriosis. In addition to dietaryinterventions, lifestyle modifications, including regular physical activity, stress management, and optimizing sleephygiene, are highlighted as integral components of comprehensive treatment plans for endometriosis patients. Furtherresearch is required to clarify the precise mechanisms underlying the relationship between diet and endometriosis andto establish evidence-based dietary recommendations personalized for patients with endometriosis.
