فهرست نشریات علمی دسترسی آزاد ایران

Background: Myomectomy is commonly performed on women diagnosed with symptomatic uterine leiomyoma(s).This study aimed to evaluate the effects of myomectomy on the serum anti-Müllerian hormone (AMH) levels inwomen with uterine myoma.Materials and Methods: In this prospective quasi-experimental study, 93 patients with uterine leiomyoma aged 18-45 years were enrolled and underwent open and laparoscopic myomectomy. The participants' baseline characteristicswere recorded. The level of AMH was measured and recorded before and six months after the surgery for each patient.The size, number, and type of myoma, the duration of surgery, the volume of bleeding during surgery, the need forblood transfusion, and postsurgical complications were investigated at 6-month intervals after the surgery. Data wereanalyzed by SPSS version 26.Results: The AMH level decreased significantly after the surgery compared to before the surgery in both groups oflaparotomic and laparoscopic myomectomy patients (P<0.001). The rate of AMH drop was lower in the laparoscopygroup than in the laparotomy group (P<0.001). Among the studied variables, changes in AMH level showed a directand significant correlation with myoma size and type. Postoperative pain, fever, and surgical site infection (SSI) werethe most frequent postsurgical complications. In post-surgical period, fever rate was 12.3% in the laparotomy group,and 6.1% in the laparoscopy group, and pain (measured by visual analogue scale) was higher in the laparotomy groupcompared to the laparoscopy group (21 vs. 7.3%). SSI rate was 0.9% in the laparoscopy group compared to 6.3% inthe laparotomy group. The size of the myoma had no significant effect on the occurrence of these complications.Conclusion: Myomectomy may lead to a significant decrease in AMH levels in women with uterine leiomyoma undergoingboth open and laparoscopic myomectomies, and the size and type of myoma significantly affects the changes in thehormone.