Investigation of The Placental Levels of Vascular Endothelial Growth Factor B and Selenoprotein P and Their Relation with Birth Weight in Patients with Pre-eclampsia: A Case-Control Study
نویسندگان
1 Children and Adolescents Health Research Center, Research Institute of Cellular and Molecular Sciences in Infectious Diseases, Zahedan University of Medical Sciences, Zahedan, Iran
2 Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
3 Children and Adolescents Health Research Center, Research Institute of Cellular and Molecular Sciences in Infectious Diseases, Zahedan University of Medical Sciences, Zahedan, Iran
4 Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
5 Department of Nutrition, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
6 Genetics of Non-communicable Disease Research Center, Zahedan of UniversityMedical Sciences, Zahedan, Iran
7 Department of Nutrition, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
8 Infectious Diseases and Tropical Medicine Research Center, Resistant Tuberculosis Institute, Zahedan University of Medical Sciences, Zahedan, Iran
doi
10.22074/ijfs.2024.2030292.1698چکیده
Background: Pre-eclampsia is a serious medical condition characterised by high blood pressure and signs of organdamage that is associated with adverse pregnancy outcomes, including low birth weight. Selenoprotein P (SELENOP) and vascular endothelial growth factor B (VEGF-B) are antioxidants that can improve the condition of this disease. This study aims to investigate the placental levels of SELENOP and VEGF-B, and their association with birth weight in pregnant women with pre-eclampsia compared to healthy pregnant women.Materials and Methods: This case-control study enrolled 30 pregnant women with pre-eclampsia as the case groupand 30 healthy pregnant women as the control group. Demographic information and anthropometric indices were collected and recorded in forms. Placental levels of SELENOP and VEGF-B were assessed by a commercial human kit and based on enzyme-linked immunosorbent assay (ELISA). P<0.05 indicated statistical significance.Results: The mean placental level of VEGF-B in pregnant women with pre-eclampsia was lower than the healthygroup (P=0.001) as was the mean placental level of SELENOP compared to the healthy group (P=0.048). No significant correlation existed between placental levels of SELENOP (r=0.253, P=0.051) and VEGF-B (r=0.671, P=0.056) with birth weight.Conclusion: Our findings showed that pregnant women with pre-eclampsia had lower levels of VEGF-B and SELENOP compared to healthy pregnant women. The findings may assist with pre-eclampsia diagnosis, management, and prediction, and benefit mothers and babies.
