Flexible Multi-dose GnRH Antagonist versus Long GnRH Agonist Protocol in Poor Responders: A Randomized Controlled Trial
نویسندگان
1 Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
2 Vali-e-Asr Reproductive Health Research Center, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
3 Endocrinology and Female Infertility Department, Reproductive Medicine Research Center, Royan Institute, ACECR, Tehran, Iran
4 Endocrinology and Female Infertility Department, Reproductive Medicine Research Center, Royan Institute, ACECR, Tehran, Iran Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
5 Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
doi
10.22074/ijfs.2009.45728چکیده
Background To compare a flexible, multi-dose GnRH antagonist protocol with a long GnRH .agonist protocol in poor respo Materials and methods A randomized clinical trial of 70 poor responder patients (35 patients in GnRH antagonist protocol and 35 patients in long GnRH agonist protocol) was performed at Royan Institute, Tehran, Iran. Both groups were given a fixed dose of human menopausal gonadotropin HMG) for stimulation and oral contraceptive pre-treatment. Data analyzed by student’s group) .t-test or Chi square test Results Stimulation duration, total gonadotrophins consumption, mean numbers of oocytes retrieved, formed embryos, cycle cancellation rate, and clinical pregnancy rate were similar between both groups. Although the miscarriage rate was higher in the agonist protocol group, the rate of .miscarriage was not statistically significant between both gro Conclusion A flexible, multi-dose GnRH antagonist protocol appears as effective as the long GnRH agonist protocol in poor responders. More (larger) randomized controlled trials for better .statistical analysis are recommended
