Identify a New Anti-Alzhimer Candidate Based on Compounds Derived from Fatty Acids by High-Throughput Screening Approach
نویسندگان
1 Department of Applied Chemistry, K. N. Toosi University of Technology, Tehran, Iran
2 Department of Medicinal Chemistry, K. N. Toosi University of Technology, Tehran, Iran
3 Department of Plant Biotechnology, Shahid Beheshti university, Tehran, Iran
4 Department of Chemistry, K. N. Toosi University of Technology, Tehran, Iran
doi
10.48309/chemm.2025.527034.1968چکیده
Alzheimer's disease (AD), which is associated with progressive memory impairment and forgetfulness, causes numerous problems not only for the patient, but also for those close to the patient. According to statistics from the World Health Organization (WHO), approximately 55 million people in the world are currently infected with this disease, and 10 million people are infected with this disease every year. Unfortunately, despite extensive research, no cure exists for this disease so far. But fortunately, every year, extensive scientific research is conducted around the world to treat this disease or decline its progression. Recent research has attempted to identify new inhibitors of the acetylcholinesterase (AChE) enzyme, one of the main enzymes effective in this disease. In this research, a high-throughput virtual screening (HTVS) procedure was used on fatty acid derivatives based on the 5, 6, and 7 carbon main chain. The result of this research was the identification of four compounds based on pentanoic acid, six compounds based on hexanoic acid, and three compounds based on heptanoic acid. Additionally, for these compounds, ADME (Absorption, Distribution, Metabolism, and Excretion) properties were obtained.
