Synthesis of 2,4,6-triaryl pyridines via decarboxylative oxidative coupling of arylacetic acids with acetophenone oximes

نویسندگان
Poordavar, Maryam ID 1
Najminejad, Zohreh ID 2
Azarifar, Davood ID 3
Sameri, Fatemeh ID 4

1 Faculty of Chemistry, Bu-Ali Sina University, 65178, Hamedan, Iran

2 Department of Chemistry, Payame Noor University, Tehran 1939-4697, Iran

3 Faculty of Chemistry, Bu-Ali Sina University, 65178, Hamedan, Iran

4 Faculty of Chemistry, Bu-Ali Sina University, 65178, Hamedan, Iran

doi
10.22036/org.chem.2024.486886.1358
چکیده

An efficient method for the synthesis of 2,4,6-triaryl pyridines has been developed through decarboxylative oxidative coupling of arylacetic acids and acetophenone oximes at room temperature. In the presence of KOH, singlet molecular oxygen was generated in situ through the fragmentation of trans-5-hydroperoxy-3,5-dimethyl-1,2-dioxolane-3-yl ethaneperoxate, and has been investigated as an efficient method for producing 2,4,6-triaryl pyridines. Further investigation showed that this procedures also permits the synthesis of asymmetric 2,4,6-trisubstituted pyridines.

کلیدواژه‌ها
Acetophenone oxime, Arylacetic acid, Singlet molecular oxygen, Trans-5-hydroperoxy-3, 5dimethyl-1, 2-dioxolan-3-yl ethaneperoxate, 2, 4, 6-Triaryl pyridine