Adipic acid as a homogenous, functional, and environmentally friendly catalyst for the solvent-free synthesis of ortho-aminocarbonitrile tetrahydronaphthalenes derivatives
نویسندگان
1 Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, Kashan, P.O. Box 87317-51167, I. R. Iran. Corresponding author
2 Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, Kashan, P.O. Box 87317-51167, I. R. Iran. Corresponding author
doi
10.22036/org.chem.2024.493362.1366چکیده
Abstract: This study explores the use of adipic acid as a homogeneous, biodegradable catalyst for the solvent-free(SF) synthesis of ortho aminocarbonitrile tetrahydronaphthalene derivatives. Emphasizing the principles of green chemistry, we demonstrate that adipic acid effectively facilitates multicomponent reactions (MCRs), yielding high product outputs (80%-99%) within short reaction times. The optimal conditions were achieved at 100°C using 0.6 mg of adipic acid in 32 minutes for a 92% yield. Our findings indicate that the electron-withdrawing substituents in the benzaldehyde derivatives enhance yields, while electron-donating groups tend to reduce them. The performance metrics, including high Turnover Numbers (TON) and Turnover Frequencies (TOF), underscore the efficiency and viability of using adipic acid as a sustainable catalyst in organic synthesis, paving the way for further research into eco-friendly catalytic processes.
