Gold Nanoparticles-Based Sensors for Colorimetric Detection of Creatinine: A Critical Review
نویسندگان
1 Chemistry Department, Faculty of Science and Technology, Jambi University, Jambi, Indonesia
2 Chemistry Department, Faculty of Teacher Training and Education, Sriwijaya University, Palembang, Indonesia
3 Chemistry Department, Faculty of Mathematic and Natural Science, Bengkulu University, Bengkulu, Indonesia
4 Chemistry Department, Faculty of Science and Technology, UIN Alauddin Makassar, Makassar, Indonesia
5 Chemistry Department, Faculty of Mathematic and Natural Science, Gadjah Mada University, Yogyakarta, Indonesia
doi
10.22036/abcr.2026.562120.2499چکیده
This review highlights recent advances in the development of colorimetric detection systems for creatinine detection using localized surface plasmon resonance (LSPR) of gold nanoparticle (AuNP)-based materials. Various strategies have been employed to enhance the sensitivity, selectivity, and practicality of AuNP-based sensors, including surface functionalization with aptamers, peptides, glutathione (GSH), ethylene diamine tetra acetic acid (EDTA), and polyols, as well as nanocomposite systems involving metal ions such as Zn²⁺ and Hg²⁺. These methods rely on mechanisms such as nanoparticle aggregation, anti-aggregation, and catalytic inhibition, enabling detection through visible color changes or spectrophotometric analysis. Additionally, integration with digital imaging, microfluidic paper-based devices (µPADs), and smartphone-based tools has improved portability and usability for point-of-care applications. Most approaches demonstrate excellent linearity, low limits of detection, and good accuracy when tested in artificial or real biological samples like urine and serum. Overall, AuNP-based colorimetric sensors offer a promising, low-cost, and efficient platform for the qualitative and quantitative detection of creatinine.
