فهرست نشریات علمی دسترسی آزاد ایران

The development of sensitive and simple methods for the determination of chemical drugs is of great interest due to their side effects. Herein, an electrochemical sensor has been proposed to determine floxuridine (Flx) based on utilizing layered double hydroxide of nickel and cobalt (NiCo-LDH). NiCo-LDH was electrodeposited on the surface of a glassy carbon electrode modified with multi-walled carbon nanotubes (GCE/CNT). LDH synthesis via electrodeposition technique enjoys advantages such as extreme speed and simplicity. The morphology of the surface of the fabricated sensor was characterized by scanning electron microscopy and the elemental analysis was performed by energy dispersive X-ray spectroscopy. To investigate the reactivity of the Flx molecule and identify the sites susceptible to electrochemical oxidation, the structure of Flx was examined by density functional theory (DFT). Comparing the electrochemical behavior of GCE/CNT and GCE/CNT/NiCo-LDH for determination of Flx in alkaline medium revealed that only NiCo-LDH has an electrocatalytic effect towards the oxidation of Flx. Under optimized conditions, the calibration curve obtained using differential pulse voltammetry technique was linear from 1.5×〖10〗^(-6) to 2.0 ×〖10〗^(-4) mol L^(-1) with a detection limit of 5.64 ×〖10〗^(-8) mol L^(-1). Furthermore, the proposed sensor has good selectivity, excellent precision, and accuracy and was successfully applied to measure Flx in pharmaceutical and human serum samples with a recovery range of 96.8–104.6 %.