Statistical Optimization and Pharmacokinetic Evaluation of Glibenclamide–Curcumin Nanosponges Prepared by Quasi-Emulsion Solvent Diffusion Technique
نویسندگان
1 Department of Pharmaceutical Chemistry, Krishna Institute of Pharmacy, Krishna Vishwa Vidyapeeth (Deemed to be University), Maharashtra 415539 Karad, India
2 Department of Pharmaceutics, Krishna Institute of Pharmacy, Krishna Vishwa Vidyapeeth (Deemed to be University), Maharashtra 415539 Karad, India
3 Department of Pharmacology, Krishna Institute of Pharmacy, Krishna Vishwa Vidyapeeth (Deemed to be University), Maharashtra 415539 Karad, India
doi
10.48309/ajca.2026.575717.2059چکیده
The present study reports the development and optimization of dual-drug nanosponges of glibenclamide and curcumin using the quasi-emulsion solvent diffusion technique to enhance controlled delivery and pharmacokinetic performance in diabetes management. A 3² factorial design was employed to optimize critical formulation variables, including polymer and stabilizer concentrations. The optimized nanosponges exhibited satisfactory physicochemical characteristics with uniform nanoscale particle size, acceptable polydispersity, high drug loading, and good colloidal stability. In vitro release studies confirmed a sustained and controlled drug release profile compared to pure active pharmaceutical ingredients (APIs). Pharmacokinetic evaluation in rabbits demonstrated prolonged systemic retention, delayed Tmax, extended mean residence time, and significantly enhanced bioavailability for nanosponge formulations compared to APIs. The optimized dual-drug nanosponges showed superior half-life and AUC values, confirming improved therapeutic performance. Overall, the findings establish quasi-emulsion solvent diffusion as a reliable and reproducible method for preparing stable nanosponges and highlight the potential of the glibenclamide–curcumin nanosponge system as an advanced drug delivery platform for improved diabetes therapy.
