Voltammetric Quantification of Idarubicin Through the Modification of Carbon Paste Electrode: A Strategy in Drug Monitoring
نویسندگان
1 School of Medicine, Bam University of Medical Sciences, Bam, Iran
2 Environment Department, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran
3 Research Center of Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman, Iran
4 Environment Department, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran
5 Environment Department, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran
doi
10.22036/abcr.2025.496685.2258چکیده
In this study, we evaluated the electrochemical performance of a carbon paste electrode (CPE) modified with CoMoO4 nanosheets (NSs) and ionic liquid (IL) for the detection of idarubicin (IDR). We began by characterizing the CoMoO4 NSs using field emission scanning electron microscopy (FE-SEM) and Fourier transform infrared spectroscopy (FT-IR) before incorporating them into the CPE . The electrocatalytic performance of the CoMoO4 NSs/IL/CPE for the electrochemical oxidation of IDR was assessed using voltammetric techniques, including cyclic voltammetry (CV), differential pulse voltammetry (DPV), and chronoamprometry. We optimized key parameters to achieve the best results . The diffusion coefficient (D) was calculated using chronoamperometry. Under optimal conditions, DPV demonstrated a linear detection range (LDR) of 4.0 to 2000.0 nM for IDR, with a detection limit (LOD) of 1.2 nM at CoMoO4 NSs/IL/CPE. Furthermore , the CoMoO4 NSs/IL/CPE was utilized to quantify IDR in real sample of idarubicine injection , yielding satisfactory results.
