Au NPs-CdS QDs Nano-composite as a New Adsorbent for Quantitative Determination of Rabeprazole in Biological and Pharmaceutical Samples Using Ion Mobility Spectrometry
نویسندگان
1 Department of Chemistry, Yazd Branch, Islamic Azad University, Yazd, Iran
2 Department of Chemistry, Yazd Branch, Islamic Azad University, Yazd, Iran
3 Department of Chemistry, Yazd Branch, Islamic Azad University, Yazd, Iran
doi
10.22036/abcr.2024.479339.2182چکیده
In this study, Au nano-particles–CdS quantum dot was synthesized and introduced as a new nano–composite adsorbent for extraction and pre–concentration of rabeprazole (RAB). The drug analyte was quantitatively retained by the adsorbent from the large volume of real samples. The desorbed RAB was determined using ion mobility spectrometry with corona discharge ionization source. Under instrumental optimum conditions (drift voltage: 6700 V, corona voltage: 2200 V, drift gas flow rate: 600.0 mL min-1, carrier gas flow rate: 300.0 mL min-1, injection port temperature: 220 ºC, cell temperature: 180 ºC and pulse width: 100 µs) RAB was determined in the range of 0.1–25.0 ng including two linear segments. The limit of detection was 0.03 ng and also limit of quantitation was found to be 0.1 ng. The precision values (RSDs%) were 7.8% and 6.9% for 1.0 and 10.0 ng of RAB, respectively. Finally, the developed method was applied for the determination of RAB in biological (human urine and serum) and pharmaceutical (tablet) samples with satisfactory recovery results.
