Synthesis, Characterization, and Biological Evaluation of Novel Tetrazole-Derived Compounds
نویسندگان
1 Department of Chemistry, College of Science, Tikrit University, Tikrit, Iraq
2 Department of Chemistry, College of Science, Tikrit University, Tikrit, Iraq
3 Ministry of Education, Salah al-Din Education Directorate, Tikrit, Iraq
4 Ministry of Education, Salah al-Din Education Directorate, Tikrit, Iraq
5 Department of Chemistry, College of Science, Tikrit University, Tikrit, Iraq
doi
10.48309/ajca.2026.545066.1918چکیده
In this study, a five-membered tetrazole ring was formed through the reaction of a prepared Schiff base with sodium azide using the sublimation method in the presence of THF as a solvent. The synthesized compounds were characterized by FT-IR spectroscopy and 1H-NMR and 13C-NMR spectroscopy, in addition to quantitative elemental analysis (C, H, and N). A TLC plate was used to track the course of the reactions. Two other Staphylococcus aureus serotypes and additional Escherichia coli serotypes were used to test the efficacy of these compounds. The results were compared with the antibiotic ampicillin. The diameter of the compounds’ inhibition was measured in mm. Compound S1 showed the highest effectiveness against the two types of bacteria used in the study compared to the other compounds. At a high dose of 0.01 mg/mL, the diameter of inhibition against Staphylococcus aureus was 23 mm, while against Escherichia coli, the diameter was 15 mm at the same concentration. It was also found that the compounds’ ability to inhibit bacterial growth increased with concentration, with higher concentrations producing greater inhibitory effects.
