فهرست نشریات علمی دسترسی آزاد ایران

Osteoarthritis is one of the most important reasons of disability. This study was conducted to investigate the correlation between serum level of 25-hydroxyvitamin D and the severity of disease in patients with knee osteoarthritis. In this descriptive (correlational) study, 506 patients with knee osteoarthritis referring to the rheumatology clinic of Rafsanjan city during 2022 were investigated. Osteoarthritis was diagnosed by a rheumatologist according to the American College of Rheumatology criteria. Serum levels of 25-hydroxyvitamin D were measured using a 5 cc non-fasting blood sample drawn from the patients. Pain intensity was assessed using the Visual Analogue Scale (VAS), and functional status was evaluated using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Statistical analysis was performed with SPSS 20 software with an alpha of 0.05. The patients' mean age was 53.75 ± 9.82 years and the frequency of women was 78.7% (398 people). Mean VAS and WOMAC scale were significantly different at various vitamin D serum levels (P < 0.001). The results of the correlation analysis showed that VAS and WOMAC scores decreased significantly with increasing vitamin D levels (P < 0.001). Based on the results of multiple linear regression model, WOMAC scale was 1.338 points lower in osteoarthritis patients with vitamin D deficiency (P = 0.024). The results of the present study demonstrated that serum 25-hydroxyvitamin D levels were associated with disease severity in patients with osteoarthritis. These findings suggest that optimizing vitamin D levels may have beneficial and clinically significant effects on improving pain and functional status.