فهرست نشریات علمی دسترسی آزاد ایران

Diabetes Mellitus (DM) is a chronic endocrine disorder associated with numerous complications, including Peripheral Arterial Diseases (PAD) and neuropathies, which significantly increase the risk of infections. In 2023, approximately 537 million  individuals  were  diagnosed  with  DM,  contributing  to  6.7  million  deaths  in  2021.  One  of  the  most  serious complications of DM is the development of Diabetic Foot Ulcers, which affect up to 25% of patients and can lead to amputation and increased mortality; however, these ulcers are also preventable. Notably, up to 50% of diabetic patients with  lower  limb  ulcers  exhibit  signs  of  PAD,  underscoring  the  critical  need  for  regular  vascular  assessments  in  this population  to  mitigate  complications.  Our  hypothesis  is  that  disturbances  in  microcirculation  contribute  to  ischemia, creating an environment conducive to infection. This study aims to investigate the histopathological manifestations and vascular changes associated with diabetic foot ulcers, focusing on the roles of vasculitis among other mechanisms. By adopting  a broader  perspective on vascular  pathology in  diabetic foot  ulcers,  we  hope  to  enhance understanding  and improve prevention strategies.