Demographic, clinical, and genetic profiles and outcomes of familial Mediterranean fever in Persian and Azeri populations: A comparative study in Kashan and Tabriz"
نویسندگان
1 Connective Tissue Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2 Infectious Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran
3 Clinical Research development unit of Kashan shahid beheshti hospital
4 Infectious Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran
5 Infectious Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran.
6 Department of Internal medicine, Faculty of medicine, Kashan university of medical sciences, Kashan, Iran.
doi
10.22034/rr.2025.232420چکیده
Familial Mediterranean fever (FMF) is an inflammatory disease that is characterized by recurring attacks of fever. This study was conducted in order to compare the demographic characteristics and outcome of patients with FMF in Kashan and Tabriz cities. This retrospective study was conducted on the files of 38 patients with FMF (19 from Kashan city and 19 from Tabriz city) who were followed up for an average of three years between 2006 and 2023. The population of Kashan is primarily of Fars ethnicity, while the population of Tabriz is Azeri. Demographic, clinical and paraclinical findings and outcome of patients were collected and analyzed using SPSS version 16 software. Outcomes of disease was assessed by auto-inflammatory diseases activity index (AIDAI) at first visit and last visited, remission rate and complications of disease, like amyloidosis. The number of male patients was higher than female patients (52.6% in Kashan and 57.9% in Tabriz groups). The median time to complete remission in Kashan patients was significantly longer than that in Tabriz patients. The percentage of general symptoms, anemia and leukocytosis in Kashan patients was significantly higher than in Tabriz. The prevalence of the heterozygous genotype in the Persian and Azeri ethnic groups was also observed in 42.1% and 44.4% of patients, respectively, which did not show a significant difference. The M694V gene mutation was found in 42.1% of Kashan patients and in 64.7% of Tabriz patients that did not differ significantly between the two groups mentioned. The average AIDAI index in the first visit in Tabriz patients was significantly lower than in Kashan. These data emphasize the role of genetic and environmental changes in causing differences in clinical, laboratory and prognosis findings of patients in different ethnic groups.
