Synthesis, Characterization, Antibacterial, and Inhibitory Activity of Cu(II)-EDTA Complex Against DENV-2
نویسندگان
1 Department of Chemistry, Faculty of Mathematics of Natural Sciences, Universitas Negeri Surabaya, Surabaya, 60231, Indonesia
2 Department of Chemistry, Faculty of Mathematics of Natural Sciences, Universitas Negeri Surabaya, Surabaya, 60231, Indonesia
3 Postgraduate School, Universitas Airlangga, Surabaya, 60286, Indonesia
4 Department of Chemistry, Faculty of Mathematics of Natural Sciences, Universitas Negeri Surabaya, Surabaya, 60231, Indonesia
5 Dengue Study Group, Institute of Tropical Disease, Universitas Airlangga, Surabaya, 60115, Indonesia
6 Department of Chemistry, Faculty of Mathematics of Natural Sciences, Universitas Negeri Surabaya, Surabaya, 60231, Indonesia
7 Department of Chemistry, Faculty of Mathematics of Natural Sciences, Universitas Negeri Surabaya, Surabaya, 60231, Indonesia
doi
10.48309/ajca.2025.522361.1843چکیده
Cu(II)-EDTA has been successfully synthesized using the solvothermal method and testes for antibacterial and anti-DENV2 activities. Cu(II)-EDTA complex compounds are characterized by FTIR, UV-Vis, SEM, DSC, and PSA. The Cu-(II)-EDTA particle size was 6.91 nm with a PDI value of 0.0808. the morphology of a crystal is a cube with a rough and irregular surface. The Cu(II)-EDTA complex demonstrated notable activity against gram-negative bacteria (Escherichia coli) and gram-positive bacteria (Staphylococcus aureus) with a zone of 8.83 ± 1.30 and 12.06 ± 1.26 mm at a concentration of 250 mg/mL, respectively. Furthermore, cytotoxicity against Vero cell and anti-DENV2 was observed with a CC50 of 415.44 μg/mL and IC50 of 270.98 μg/mL, suggesting their potential use as antibacterial against E. coli, S. aureus, and anti-DENV2 agent.
