فهرست نشریات علمی دسترسی آزاد ایران

This study presents the solubility values of naproxen (NAP) in binary mixtures of isopropanol and propylene glycol (PG) with varying mass fractions of isopropanol. The bioavailability of an oral drug depends mainly on its ability to dissolve in the digestive system and pass through the cell membrane. It is important to enhance its solubility using various solvents and mathematical models. The solubility values at temperatures ranging from 293.2 to 313.2 K were determined using the shake-flask method. The solubility of NAP increases as the mass fraction of isopropanol increases, reaching its maximum value at w1 = 0.7. The solubility of NAP was modeled using various cosolvency models, and the model parameters were calculated. The Jouyban-Acree model is used to determine the density of saturated mixtures at various temperatures. The accuracy of this model is measured by calculating the mean relative deviations (MRD %) of the back-calculated solubility and density data. The overall MRD% values were: Van’t Hoff equation: 1.8%, MRS model: 2.0%, Jouyban–Acree model: 2.2%, Modified Wilson model: 1.8%, Jouyban-Acree-van’t Hoff model: 2.8%. The apparent thermodynamic properties of NAP dissolution are determined using back-calculated solubility and density data, as well as the van't Hoff and Gibbs equations.