Synthesis and Characterization of New Imidazol-5-one Azo Compounds from Acrylic Acid and Their Biological Activity Study
نویسندگان
1 Applied Biotechnology Department, College of Biotechnology, Al-Qasim Green University, Babylon, Iraq
2 Thiqar Government, Thi-Qar, Iraq
3 Educational Directorate Thi-Qar, Thi-Qar, Iraq
4 Chemical Engineering Department, College of Engineering, University of Babylon, Babylon, Iraq
doi
10.48309/ajca.2025.463958.1566چکیده
Synthesis of new imidazol-5-one azo compounds 5-((E)-benzylidene)-3-(4'-((Z)-phenyldiazenyl)-[1, 1'-biphenyl]-4-yl)-2-vinyl-3, 5-dihydro-4H-imidazol-4-one and its derivatives has been studied in this work. The reaction of an α, β-unsaturated carboxylic acid with thionyl chloride as starting materials led to (E)-4-benzylidene-2-vinyloxazol-5(4H)-one (compound A3) after two steps which was treated with benzidine, and then aromatic compounds in the presence of sodium nitrite and hydrogen chloride at low temperature due to compounds A5-A7 via a coupling reaction. The synthesized compounds were characterized by FT-IR, 1H-NMR, and 13C-NMR spectroscopy. The studies of antibacterial and antioxidant activities indicate that some of these molecules to be developed as a potential antibacterial and antioxidant agents.
