Synthesis, Characterizations, Biological Activity and Molecular Docking Study of New Azo Schiff -Bases
نویسندگان
1 Department of Chemistry, College of Science, University of Baghdad, Baghdad, Iraq
2 Department of Chemistry, College of Science, University of Baghdad, Baghdad, Iraq
doi
10.48309/ajca.2024.464448.1573چکیده
A new Schiff base (5) was synthesized by reacting the hydrazide derivative (3) with p-aminoacetophenone in the presence of a few drops of H2SO4 in ethanol as a solvent. Following this preparation, the diazonium salt was prepared by reacting compound (6) with sodium nitrate in the presence of HCl at 0-5 °C and performing a coupling reaction. This reaction involved the prepared diazonium salt and some substituted phenols, leading to the formation of the corresponding azo-Schiff bases 7(a–e). Target compounds were identified using FT-IR, 1H-NMR and 13C-NMR. The second part of the current work includes the investigation of molecular docking and biological activities such as antimicrobial and antifungal effects.
