فهرست نشریات علمی دسترسی آزاد ایران

Background and objectives: Sexual issues, especially erectile dysfunction, are common among men undergoing methadone maintenance treatment (MMT). This study aimed to explore the effects of a Persian Medicine product, “Dava al-basal”, on erectile dysfunction and testosterone levels in men receiving MMT. Methods: This double-blind randomized clinical trial involved 60 men who were randomly assigned to two groups. The intervention group received 20mL of “Dava al-basal” daily, a syrup composed of white onion juice, ginger, and honey, while the placebo group received a simple syrup for eight weeks. Participants were evaluated before the intervention and again at the end of the study using the International Index of Erectile Function Questionnaire (IIEF) and measuring total testosterone levels. Results: The IIEF scores showed no significant changes following the interventions in either group (p-value>0.05). In the intervention group, participants had a testosterone level of 197.67±23.08 ng/dL at the beginning of the study, which increased to 325.23±32.73 ng/dL after the intervention (p-value<0.001). In contrast, the placebo group had a testosterone level of 215.33±28.35 ng/dL before the intervention, which decreased to 194.17±32.46 ng/dL afterward (p-value = 0.047). The results indicated a 64% increase in testosterone levels in the intervention group, compared to a 10% decrease in the placebo group; the difference was statistically significant (p-value<0.001). Conclusion: "Dava al-basal", showed the potential to increase testosterone levels in men undergoing MMT; however, it did not enhance their sexual function. Further research with longer intervention periods and the assessment of additional laboratory indices is recommended to validate the findings of this study.