Synthesis of Zn-doped Ni-MOF Bearing Pd, Mn3O4 and Ag2MnO4 Nanoparticles and Investigation of Their Anticancer Activity Against AGS Cell Lines
نویسندگان
1 Department of Chemistry, Shahrekord University, Shahrekord, Iran.
2 Department of Genetics, Shahrekord University, Shahrekord (115), Iran
3 Department of Chemistry, Shahrekord University, Shahrekord, Iran.
doi
10.22036/org.chem.2024.463817.1340چکیده
Pd, Mn3O4 and Ag2MnO4 nanoparticles embedded on Zn-doped Ni-MOF were successfully prepared. The obtained nanostructures (7–20 nm) were well characterized. They were good fluorescent materials. The nanostructures have significant anticancer activity against gastric cancer cells, based on the results of the MTT assay (24 and 48 h) and in this regard Mn3O4/Pd/Zn-Ni-MOF, Ag2MnO4/Pd/Zn-Ni-MOF showed superior effectiveness. The measured IC50 values ranged from 89.41–377.67. The expression of caspase 3, 8 and 9 genes in the treated cells of [Zn-Ni-MOF], 2-PySI@[Zn-Ni-MOF], 2-PySI-Pd@[Zn-Ni-MOF], Mn3O4/Pd/Zn-Ni-MOF, Ag2MnO4/Pd/Zn-Ni-MOF, Mn3O4, and Ag2MnO4 nanostructures was also investigated and multifold increases compared to the control were observed in all cases.
