Four-component Cascade Reaction was Programmed and Catalyzed by B(OH)3.H2O as an Efficient and Green Catalytic System
نویسندگان
1 Sayyed Jamaleddin Asadabadi University, Asadabad, 6541835583, I. R. Iran.
2 Khajeh Nasir Toosi University, Tehran, Iran
3 Sayyed Jamaleddin Asadabadi University, Asadabad, 6541835583, I. R. Iran
4 Department of Chemistry, University of Sayyed Jamaleddin Asadabadi, Asadabad 6541835583, Iran
doi
10.22036/org.chem.2018.122359.1133چکیده
An aqueous solution of boric acid, as an efficient and green catalytic system, was efficiently utilized four-component cascade reaction of aryl aldehydes, dimedone, β-ketoesters and ammonium acetate to give hexahydroquinolines. By the reaction of boric acid with water, H+ was generated and efficiently catalyzed the reaction under mild and green condition. Also, optimization of the reaction condition was investigated using the response surface method {Central Composite Design (CCD)}.
