فهرست نشریات علمی دسترسی آزاد ایران

Introduction: Improving the metabolism of skeletal muscle is one of the important mechanisms for the treatment oftype 2 diabetes. The aim of this study was to evaluate the effect of high-intensity interval training (HIIT) on gene expression of the factors involved in the skeletal muscle metabolism of diabetic rats.Materials and Methods: To implementation of this experimental research, 48 male Wistar rats weighing 220 ± 20 gr randomly were divided into 4 groups including control, diabetes, training and diabetes-training. In this study, therats become diabetes type 2 using peritoneal injection nicotinamide-STZ. High-intensity interval training performed with intensity of 80-85% VO2max, 5 days a week and for 8 weeks. The expression of GLUT4 and PGC-1α genes were measured by Real Time PCR. Data were analyzed by One-way ANOVA and Tukey post hoc test at the P<0.05.Results: The results showed a significant difference between the mean expression of GLUT4 and PGC-1α of skeletal muscle in diabetic rats in different groups (P< 0.001). The changes in the expression of GLUT4 and PGC-1α of the skeletal muscle in the diabetes group were significantly lower than the control group (P=0.036). High-intensity interval training significantly caused higher the expression of GLUT4 and PGC-1α (P< 0.001).Conclusion: According to the findings of the present study, high-intensity interval training can help to improve cellular energy levels during diabetes as a result of increasing the expression of PGC-1α and GLUT4 in skeletal muscle.