Synthesis of Quinazolinone Derivatives through Multicomponent/Click Reactions

نویسندگان
Afsar, Seyedeh Yasaman ID 1
Mohammadi Ziarani, Ghodsi ID 2
Gholamzadeh, Parisa ID 3
Badiei, Alireza ID 4

1 Chemistry, Alzahra University

2 Alzahra University

3 Chemistry, Alzahra university

4 University of Tehran

doi
10.22036/org.chem.2018.109157.1117
چکیده

Quinazolinones were synthesized through the one-pot three-component reaction of aromatic aldehydes, isatoic anhydride, and urea under solvent-free conditions using sulfonic acid functionalized mesoporous silica (SBA-Pr-SO3H). The propargyl ether containing 2,3-dihydroquinazolin-4(1H)-ones were reacted with sodium azide in the presence of CuI to gain the new triazole-quinazolinone products.

کلیدواژه‌ها
Dihydroquinazolinone, Quinazolinone, SBA-Pr-SO3H, Click reaction, Isatoic anhydride