فهرست نشریات علمی دسترسی آزاد ایران

In cancer treatment, curcumin is recognized as one of the oldest and most effective agents. A significant challenge in using curcumin is its hydrophobic nature, which limits its clinical application. Encapsulating hydrophobic drugs has the potential to enhance their bioavailability and therapeutic effectiveness. Electrospray technology has recently emerged as a promising method for producing drug-loaded nanoparticles. Electrospray has been extensively studied for its applications in drug delivery. This study successfully encapsulated curcumin in poly(caprolactone) (PCL)-polyvinyl alcohol (PVA) nanocapsules for drug delivery. Due to their biocompatibility, controlled release characteristics, and ability to prevent degradation of the encapsulated drug, PCL-PVA nanoparticles have been considered promising drug carriers. The drug loading capacity (DLC%) and encapsulation efficiency (EE%) for curcumin were determined to be 83.3% and 8.81%, respectively. The nanoparticle size distribution was narrow, with an average size of 151.9 nm. Additionally, nanoparticle characterization was conducted using SEM, FT-IR, and XRD. While an initial burst release was noted within the first 20 h of in vitro testing, sustained release was observed over 140 h. This research has demonstrated the use of PCL-PVA nanoparticles as effective drug delivery systems, showcasing both controlled release properties and the ability to protect against medication degradation. These findings represent a significant step forward in ongoing efforts to develop novel nanoparticle formulations for improving cancer treatment approaches.