The Relationship Between Serum Adrenomedullin, Pentraxin3 Levels and Successful Implantation in Assisted Reproductive Techniques Cycles
نویسندگان
1 Department of Fertility and IVF, Al Sadder Medical City, Al Najaf Teaching Hospital, Al Sadder Medical City, Al Najaf Al Ashraf, Iraq
2 Department of Obstetrics and Gynecology, Kamal Al-Samarraei Hospital for Infertility Treatment and IVF, Baghdad, Iraq
3 Department of Fertility and IVF, Alzahraa Teaching Hospital, College of Medicine, Kufa University, Kufa, Iraq
4 Department of Fertility and IVF, Al Sadder Medical City, Al Najaf Teaching Hospital, Al Sadder Medical City, Al Najaf Al Ashraf, Iraq
doi
10.30699/jogcr.9.5.507چکیده
Background & Objective: A competent embryo, receptive endometrium and a series of highly coordinated molecular events between them are all essential for successful implantation. Evaluation of certain molecules which may be used as biomarkers may help to predict pregnancy outcome and detect subtle implantation defect. The present study was conducted with aim to assess the relationship between serum concentrations of adrenomedullin (ADM) and pentraxin3 (PTX3) measured at the day of embryo transfer and successful implantation in assisted reproductive technique cycles.Materials & Methods: This prospective cohort study included 88 frozen embryo transfer (FET) cycles. All patients received sequential oestrogen & progesterone medications. Embryo transfer (with a minimum of one top quality embryo) was scheduled after 4 days (D3 embryo), 6 days (D5 embryo) of progesterone administration. The serum ADM and PTX3 levels were analyzed 1 hour before the embryo transfer (ET) using ELISA kits. A possible association between these two markers levels and embryo implantation was evaluated.Results: Overall, biochemical pregnancy rate was 25% (22/88). Data were then categorized into pregnant (22/88) & non-pregnant (66/88). No significant difference were found between the two groups regarding female age, endometrial thickness, number of oocyte collected, oestradiol level (E2), FSH level, grade and number of embryo transferred (P>0.05). The ADM levels were higher on the day of ET, although was not significant in pregnant group (254.60 pg/ml vs 248.18pg/ml). PXT3 levels (pg/ml) were lower in pregnant compared to non-pregnant group (25.396±11.78 vs 28.431±16.51, P=0.428).Conclusion: Higher ADM and lower PTX3 levels at the day of embro transfer may be associated with successful implantation.
