فهرست نشریات علمی دسترسی آزاد ایران

This study introduces an iron oxide modified with melamine-based dendrimer (IO@MBD) as a new pH-responsive nanomagnetic carrier for doxorubicin delivery. A comprehensive set of techniques was employed to characterize the structure of IO@MBD, including Fourier-transform infrared spectroscopy (FT-IR), dynamic light scattering (DLS), zeta potential measurements, X-ray diffraction (XRD), transmission electron microscopy (TEM), field emision scanning electron microscopy (FESEM), energy-dispersive spectroscopy (EDS), thermogravimetric analysis (TGA), vibrating sample magnetometry (VSM), and carbon-hydrogen-nitrogen (CHN) analysis. The as-prepared magnetic nanoparticles were conjugated to the anticancer drug doxorubicin (DOX) through Schiff-base linkage. This system showed a pH-responsive pattern in DOX release analysis in simulated pH values of (5.5, 6.5, and 7.4) at various time intervals. The in vitro cell cytotoxicity was performed on a breast cancer cell line (MCF-7). The results showed that DOX-conjugated nanoparticles have a toxicity that is comparable to that of free DOX with higher efficacy within 48 hours. It is notable that IO@MBD contains only a 1.5-generation dendrimer, and so the use of costly compounds in nanocarrier synthetic steps decreases. This property results fewer laboratory operations and lower overall costs. These findings, together with the high hydrophilic character and dispersity of the present nanocarrier suggest that the present drug delivery system holds significant potential as an effective anti-cancer agent, offering targeted release capabilities that could enhance therapeutic outcomes in cancer treatment.