فهرست نشریات علمی دسترسی آزاد ایران

The examination of the biocompatibility and stability of zinc oxide nanoparticles (ZnONPs) synthesized from plants is a significant area of research in nanotechnology due to its widespread applications in biomedical, industrial, cell imaging, and biosensor fields. This study introduces a novel approach for producing stable ZnONPs utilizing zinc nitrate and extracts from Lagerstroemia speciosa leaves as a proficient chelating agent. The cytotoxic and antiproliferative effects of the Lagerstroemia speciosa mediated synthesized zinc oxide nanoparticles (Ls-ZnONPs) on human breast cancer cell lines were evaluated using several assays. The synthesized Ls-ZnONPs were characterized using several spectroscopic and microscopic methods. The MTT assay was employed to assess the cytotoxic effects of ZnONPs on MCF-7 cells. The apoptotic potential was evaluated with a fluorescence microscopy approach. The UV-vis spectroscopy investigation revealed an absorption peak at a wavelength of 261 nm. The efficacy of bioactive compounds from Lagerstroemia speciosa in stabilizing Ls-ZnONPs was confirmed using X-ray diffraction and Fourier transform infrared analysis. The DLS tests indicated an average size of 60 nano-meters and a zeta potential of -8.5 mV. The scanning electron microscopy (SEM) examinations revealed that the particle exhibited a spindle shape. The biosynthesized Ls-ZnONPs demonstrated considerable antibacterial efficacy. Moreover, the biosynthesized Ls-ZnONPs demonstrated significant cytotoxic effects on MCF-7 breast cancer cell lines in a dose-dependent manner. In conclusion, the Ls-ZnONPs were synthesized using a dependable, straightforward, and eco-friendly approach utilizing an extract from Lagerstroemia speciosa leaves. The biosynthesized Ls-ZnONPs demonstrated significant cytotoxicity against metastatic breast cancer cell line.