CuFe2O4@SiO2-EA: A Novel, Green, and Recyclable Nanomagnetic Catalyst for Synthesis of Pyrimido[4,5-d] Pyrimidines Derivatives
نویسندگان
1 Department of Chemistry, Faculty of Basic Sciences, Ilam University, P.O. Box 69315516, Ilam, Iran
2 Department of Chemistry, Faculty of Basic Sciences, Ilam University, P.O. Box 69315516, Ilam, Iran
doi
10.48309/jaoc.2025.492516.1254چکیده
In this study, a new magnetic nanoparticles functionalized with ethylamine (CuFe2O4@SiO2-EA) was synthesized as a heterogeneous and recyclable catalyst. This catalyst was used in the synthesis of pyrimido[4,5-d]pyrimidine derivatives via one-pot three-component reaction of aromatic aldehydes, barbituric acid/thiobarbituric acid, and urea/thiourea in water solvent at 80 °C. Techniques including scanning electron microscopy (SEM), thermal gravimetric analysis (TGA), X-ray diffraction (XRD), transmission electron microscopy (TEM), vibrating sample magnetometry (VSM), and energy dispersive X-ray analysis (EDX) were used to elucidate the catalyst structure. Due to the magnetism of these nanocatalysts, they can be easily separated from the reaction medium using a simple magnet and used multiple times without significant reduction in catalytic activity.
