Association of Anti-Müllerian Hormone on Oocyte Maturation, Fertilization, and Pregnancy Rates in Patients under Assisted Reproductive Technology Cycles: A Cross-Sectional Study
نویسندگان
1 Department of Statistics, Faculty of Mathematical Sciences, University of Kashan, Kashan, Iran
2 Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
3 School of Medicine, Isfahan University of Medical Science, Isfahan, Iran
4 Department of Biostatistics and Epidemiology, School of Public Health, Loma Linda University, Loma Linda, CA, USA
5 Department of Biostatistics, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran
6 Department of Statistics, Faculty of Mathematical Sciences, University of Kashan, Kashan, Iran
7 Department of Applied Mathematical Sciences, Yazd University, Yazd, Iran
8 Department of Mathematics, Imam Reza International University, Mashhad, Iran
9 Department of Statistics, Faculty of Statistics Mathematics and Computer, Allameh Tabataba’i University, Tehran, Iran
doi
10.22074/ijfs.2023.1988282.1428چکیده
Background: Ovarian reserve is one of the most important factors that influences the success of assisted reproductivetechnology (ART). Recently, the role of anti-müllerian hormone (AMH) in ART has been investigated as a marker forthe prediction of ovarian response. We aim to examine this relationship within a large Iranian population.Materials and Methods: In this cross-sectional study, we obtained data from 1000 infertile couples who referred tothe Research and Clinical Centre of Yazd Infertility Clinic for in vitro fertilisation (IVF) or intracytoplasmic sperminjection (ICSI). Serum AMH levels, oocyte count, numbers of fertilised oocytes, endometrial thickness, and percentageof mature oocytes were measured. The relationship between AMH serum levels and the number and quality ofoocytes and embryos in ART cycles was analysed.Results: In the linear regression model, the log of the variables total dose of gonadotropin, two pronuclei (2PN), logoestradiol, total embryos, duration of stimulation, number of embryos transferred, protocol, and cause of infertilitywere significant predictors of log AMH.Conclusion: There appears to be a relationship between serum AMH levels in the early follicular phase and ovarianreserve. Higher serum AMH levels were also associated with shorter ART cycles.
