Box-Behnken Experimental Design Method Applied to Optimize Photo-Fenton Degradation of Pharmaceutical Atorvastatin Calcium in Aqueous Solution
نویسندگان
1 Mohamed El Bachir El Ibrahimi University, Bordj Bou Arreridj, ALGERIA
2 Centre de Développement des Energies Renouvelables, CDER, BP 62 Route de l’Observatoire, Bouzaréah, Algiers, ALGERIA
3 Unité de Développement des Equipements Solaires, UDES, Centre de Développement des Energies Renouvelables, CDER, Tipaza, ALGERIE
doi
10.30492/ijcce.2023.559326.5487چکیده
Due to the harmful effects on the environment and public health, Atorvastatin calcium (ATO) has to be removed from wastewater using the photo-Fenton process. The novelty of this study is based on the modeling and the optimization of the operating parameters affecting the efficiency of the process by using the Box-Behnken Design (BBD). Operating factors such as pollutant concentration [20-40 mg/L], iron concentration [1-5 mM], and H2O2 concentration [5-10 mM] were investigated to evaluate the Chemical Oxygen Demand (COD) abatement. A mathematical model of pollutant degradation was established using the MODDE 6.0 software and statistical analysis showed good agreement between experimental results and predictive values with an error of less than 5%, which indicates the soundness of the developed model. The results suggested that the most influential factor on the photo-Fenton degradation of the drug was the initial ATO concentration with an effect of (-22.86), the second was the amount of the H2O2 with an effect of (+2.82), the third was the concentration of Fe3+ ions with an effect of (-2.79). The model obtained by BBD corresponding to the best value of the COD abatement rate (100%) of ATO led to the following optimal conditions: initial concentration of pollutant equal to 20 mg/L, a catalyst concentration equal to 1 mM and a concentration of hydrogen peroxide equal to 10 mM.
