The Role of Arginine-Phenylalanine-Amide-Related Peptides in Mammalian Reproduction
نویسندگان
1 Department of Animal Science, College of Agriculture, Shiraz University, Shiraz, Iran
2 Transgenic Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
3 Department of Animal Science, College of Agriculture, Shiraz University, Shiraz, Iran
4 Department of Animal Science, College of Agriculture, Shiraz University, Shiraz, Iran
5 Histomorphometry and Stereology Research Center, Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
doi
10.22074/ijfs.2015.4540چکیده
Until 2000 it was believed that gonadotropin-releasing hormone (GnRH) was the sole regulator of hypophyseal gonadotropes. In 2000, the discovery of a gonadotropin inhibitory hormone (GnIH) initiated a revolution in the field of reproductive physiology. Identification of GnIH homologues in mammals, the arginine-phenylalanine-amide (RFamide)-related peptides (RFRPs), indicated a similar function. Subsequently, further works conducted in various laboratories worldwide have shown that these neuropeptides inhibit the hypothalamic-hypophyseal axis. This review discusses the role of RFRPs in mammalian reproductive processes.
