Chemical Composition and Biological Activities of Essential Oil and Methanol Extract of Teucrium scordium
نویسندگان
1 Medical Biotechnology Research Center, Ashkezar Branch, Islamic Azad University, Ashkezar, Yazd, I.R. IRAN
2 Medical Biotechnology Research Center, Ashkezar Branch, Islamic Azad University, Ashkezar, Yazd, I.R. IRAN
3 Medical Biotechnology Research Center, Ashkezar Branch, Islamic Azad University, Ashkezar, Yazd, I.R. IRAN
4 Department of Medicine, Yazd Branch, Islamic Azad University, Yazd, I.R. IRAN
5 Department of Medicine, Yazd Branch, Islamic Azad University, Yazd, R. IRAN
doi
10.30492/ijcce.2020.36074چکیده
In this study, the chemical composition of the essential oil of Teucrium scordium was studied using capillary GC and GC/MS instruments. In addition, the antimicrobial and cytotoxic activities of the oil and methanol extract were evaluated by disc diffusion and MTT assays, respectively. Forty-three volatile components were identified from the oil of aerial parts, representing of 98.1% of total oil. The major constituents were trans-α-bergamotene (52.3%), (Z)-α-trans-bergamotol (18.1%), linalool (3.0%) and piperitenone oxide (2.9%). The best anti-bacterial activity was observed for the methanol extract against Staphylococcus epidermidis with ZI (19.0 ± 0.47) mm and also against Proteus mirabilis with MIC value of 1.25 µg/mL.Investigation of the samples on cell viability of HeLa cells showed good activity for the essential oil with an IC50 value of 5.2 µg/mL. Our results indicated that Teucrium scordium can be considered for further analyses as an effective and safe curing agent for cancer and pathogenic infection therapies.
