فهرست نشریات علمی دسترسی آزاد ایران

Introduction: With the increasing prevalence of diabetes worldwide, it seems that resistance training can reduce cardiac dysfunction in diabetic models. The aim of the present study is the effectiveness of resistance training on reticulophagy-related proteins in the left ventricle of the heart of type 2 diabetic rats.Materials and Methods: In this experimental study, 12 2-month-old male Sprague Dawley rats with an average weight of 280±20 grams were selected. Type 2 diabetes was induced by injecting nicotinamide and streptozotocin solutions. Rats were randomly divided into the diabetic resistance training group and the diabetic control group. Resistance training consisted of 8 weeks and 3 sessions per week of climbing a vertical ladder with an 85degree slope, one meter long with 26 steps and 2 cm space between each step. To analyses the data, independent t-tests, and t-dependent tests were used in SPSS version 29 software.Results: The protein content of ATF6 (P=0.001) and mTOR (P=0.03) showed a significant decrease and increase, respectively, compared to the control group in the left ventricle of the heart after 8 weeks of resistance training. On the other hand, there was no significant change in JNK1 protein content in the left ventricle of the heart (P=0.16). The level of blood sugar (mg/dl) did not show a significant change between the eighth week compared to the first week in the resistance training group (P=0.07), but a significant difference was observed between the eighth week in the control group compared to the resistance training group (P=0.001).Conclusion: It seems that resistance training for 8 weeks is capable of modulating proteins related to reticulophagy in the heart of people with type 2 diabetes.