Multicomponent Solvent-Free Synthesis, Antimicrobial and Antifungal Evaluation of Novel N-Amino Benzylthiolates
نویسندگان
1 Department of Chemistry, Faculty of Science, University of Zabol, Zabol, Iran
2 Department of Chemistry, Faculty of Science, University of Zabol, Zabol, Iran
3 Department of Chemistry, Faculty of Science, University of Zabol, Zabol, Iran
doi
10.22036/org.chem.2018.121376.1130چکیده
Novel N-amino benzylthiolates were synthesized via multicomponent reaction of malononitrile, isothiocyanates and benzyl halides under conventional and solvent-free conditions. Various electron-donating and -withdrawing substitutes within both isothiocyanates and benzyl halides were used to demonstrate the efficiency of new methodology. A broad spectrum of antibacterial and antifungal activities were observed especially within benzyl halides containing electron-withdrawing aryl substituents.
