One Pot Synthesis of Highly Functionalized Tetrahydropyridines Using Nano-TiCl2/cellulose as Biodegradable and Eco-Friendly Catalyst
نویسندگان
1 Yazd University
2 chemistry department , yazd university
3 Departent of Organic Chemistry, Faculty of Chemistry, University of Kashan
doi
10.22036/org.chem.2018.125678.1134چکیده
TiCl4/nano-cellulose as a biodegradable and eco-friendly Lewis acid catalyst was synthesized via reaction of nano-cellulose and TiCl4. This catalyst was characterized and used for synthesis of asymmetric highly functionalized tetrahydropyridines via a five-component condensation reaction of p-substituted anilines, aldehydes and ethyl acetoacetate under solvent-free condition. Simple methodology, eco-friendly catalyst, clean procedure, easy work-up and high yields are some of the important advantages of this protocol.
