Synthesis of Novel Thiazole Based 1,2,3-Triazole Derivatives as Inhibitors of Glioblastoma Cancer Cells
نویسندگان
1 Geethanjali College of Engineering and Technology, Cheeryal, Keesara, Medchal, 501301 Telangana, India
2 Department of Chemistry, University College of Science, Osmania University, Hyderabad, 500007, Telangana, India
3 Department of Sciences and Humanities, Matrusri Engineering College, Saidabad, Hyderabad, 500059, Telangana, India
4 Department of Chemistry, University College of Science, Osmania University, Hyderabad, 500007, Telangana, India
5 Department of Chemistry, University College of Science, Osmania University, Hyderabad, 500007, Telangana, India
doi
10.48309/AJGC.2025.491225.1603چکیده
A library of thiazole – 1,2,3-triazole hybrids through the conventional 1,3-dipolar cycloaddition reaction of ethyl 2-(3-formyl-4-(prop-2-yn-1-yloxy) phenyl)-4-methylthiazole-5-carboxylate based alkyne via click reaction. Spectral data, such as IR, 1H-NMR, 13C-NMR, and Mass, were used to characterize the molecules structures. Synthesized compounds were screened for in vitro anticancer effects on human glioblastoma cell lines. Some compounds displayed potent activity with IC50 values of 10.67±0.94 µM, 4.72±3.92 µM, and 3.20±0.32 µM, in contrast to reference drug Temozolomide. Computational study against thymidylate synthase demonstrated favourable docking scores and binding interactions like H-bond, π-π stacked, and π-sulfur.
