Synthesis, Molecular Docking, and Biological Evaluation of Some New Naphthalene-Chalcone Derivatives as Potential Anticancer Agent on MCF-7 Cell Line by MTT Assay
نویسندگان
1 Department of Chemistry, Kai. Rasika Mahavidyalaya Deoni, Dist. Latur, 413519, (M.S.), India
2 Department of Chemistry, K. M. C. College Khopoli, Dist. Raigad, 410203, (M.S.), India
3 Department of Chemistry, Swami Vivekanand Sr. College Mantha, Dist. Jalna, 431401(MS), India
4 Department of Chemistry, Swami Vivekanand Sr. College Mantha, Dist. Jalna, 431401(MS), India
5 Department of Chemistry, Sant Gadge Baba Amravati University, Amravati, 444602 (MS), India
6 Shri Vyankatesh Arts, Commerce and Science College Deulgaon Raja, Dist. Buldana, 443204 (MS), India
7 Department of Chemistry, Aavvaiyar Government College for Women Karaikal, Pondicherry, 609602, India
doi
10.48309/ajgc.2024.418444.1458چکیده
Naphthalene chalcones (3a-i) with excellent yields were achieved through the use of aromatic ketones, 1-naphthaldehyde, and aqueous NaOH in the synthesis process. The synthesized chalcones were bio-evaluated as potential tubulin polymerization inhibitors for the treatment of breast cancer. The antiproliferative potential of each synthesized compound against the MCF-7 cell line was assessed. The majority of the compounds showed strong antiproliferative properties. With an IC50 value of 222.72 µg/mL, compound 3f exhibited the most antiproliferative activity among them, surpassing that of 5FU (IC50, 51.47 µg/mL).
