Saccharin as a new organocatalyzed: a fast, highly efficient and environmentally friendly protocol for synthesis of imidazo[1,2-α]pyridine derivatives via a one-three component reaction

نویسندگان
Ramezanpour, Sorour ID 1
Rominger, Frank ID 2
Bigdeli, Zahra ID 3

1 Department of Chemistry , K. N. Toosi University of Technology, P.O. Box 15875-4416 Tehran, Iran

2 Organisch-Chemisches Institut der Universitaet Heidelberg, Im Neuenheimer Feld 270, 69120 Heidelberg, Germany

3 Department of Chemistry , K. N. Toosi University of Technology, P.O. Box 15875-4416 Tehran, Iran

doi
10.22034/AJGC/2020.1.7
چکیده

In this research article, we report the synthesis of imidazo[1,2-a]pyridine derivatives through Ugi condensation in the presence of saccharin as an organocatalyst used in a three component reaction. The convenient synthetic protocol, short reaction times, easy work up, good to excellent yields and mild reaction conditions make this process both practical and attractive.

کلیدواژه‌ها
Three-component reaction Ugi condensation Saccharin Imidazo[1, 2-α]pyridine