فهرست نشریات علمی دسترسی آزاد ایران

This study investigates the potential of chitosan-based Drug Delivery Systems (DDS) for the effective delivery of aripiprazole, an atypical antipsychotic, in the help of treatment of narcissistic personality disorder (NPD). The research shows a multifaceted approach, utilizing advanced analytical techniques and mathematical formulas to thoroughly characterize the physicochemical properties, bioactivity, and performance of the aripiprazole-loaded using DDS. Morphological analysis shows that higher concentrations of aripiprazole contribute to increased surface complexity and porosity, which can improve drug loading and release capabilities. We prepared chitosan and alginate solutions, encapsulated aripiprazole using a coacervation method, and freeze-dried the drug-loaded beads. Morphological analysis was conducted using scanning electron microscopy (SEM), and drug loading efficiency, nuclei formation, and degradation rate were quantified using mathematical formulas. The optimization of formulation parameters, such as porosity and degradation rate, suggests the potential for the developed DDS to provide sustained and targeted delivery of aripiprazole, potentially improving treatment outcomes for individuals with NPD. The chitosan-based DDS showed a loading efficiency of 72-95%, apatite formation of 15-21%, and degradation rate of 22-38%, effectively encapsulating aripiprazole and showing favorable properties for treating NPD. Comprehensive characterization and optimization are crucial for developing personalized delivery approaches. The integration of advanced characterization techniques and mathematical modeling in this study shows the importance of a comprehensive approach to DDS development, paving the way for more personalized and effective treatment strategies for complex psychiatric disorders like NPD, brain relaxation, or motion regulation.