فهرست نشریات علمی دسترسی آزاد ایران

Diabetic ketoacidosis (DKA) is a serious complication of diabetes, more common in type 1 diabetes, but it can also occur in type 2 diabetes. It involves high blood glucose, dehydration, and acidic ketone build-up, with 3-hydroxybutyrate acid (3-HB) being a primary ketone indicating insulin deficiency. Monitoring 3-HB is vital for diagnosing and managing DKA. This study aimed to synthesize molecularly imprinted polymers (MIPs) using 3-hydroxybutyrate acid as a template, creating a selective sorbent that could serve as a cost-effective and efficient alternative to conventional diagnostic tools for diabetic ketoacidosis (DKA). The MIPs were characterized using Scanning Electron Microscopy (SEM) and Fourier Transform InfraRed (FT-IR) spectroscopy to confirm their morphology, chemical structure, and presence of imprinted sites specific to 3-hydroxy butyrate (3HB). Batch rebinding and isotherm adsorption profiles of MIP and NIP were evaluated using the batch method in ethanol at a concentration of 20-60 ppm. The FT-IR spectra of NIP01, MIP01, and MIP03 were analyzed to compare their spectral absorbance profiles and the types of vibration observed in their different compositions. The results demonstrated a significant difference in the batch rebinding and adsorption profiles between Non-Imprinted Polymers (NIPs) and MIP under the 3HB condition, with MIP04 showing consistently higher performance, achieving up to 93.12% at 20 ppm, and maintaining strong adsorption at higher concentrations, with 91.48% at 50 ppm and 90.81% at 60 ppm. These findings confirmed the superior performance of MIPs, particularly MIP04, in selectively capturing 3HB molecules, highlighting the significant advantage of molecular imprinting in enhancing the polymer's adsorption efficiency and selectivity.