فهرست نشریات علمی دسترسی آزاد ایران

For medicinal chemists, natural products have always been the only source of viable lead compounds. They have also provided a broad range of possible drug candidates to clinical practice for the treatment of a wide spectrum of illnesses and disorders. In this study, compared to acarbose, garcinoic acid compound shows promise as an inhibitor of both α-amylase and α-glucosidase based on the computed IC50 values. Based on its strongest α-amylase inhibitory activity and highest α-glucosidase activity, the natural compound may have dual inhibitor potential. In this investigation, both enzymes were inhibited by garcinoic acid molecule with excellent to good IC50 values of 28.91 ± 3.61 µM for α-amylase and 41.08 ± 6.03 µM for α-glucosidase. Also, this compound was also investigated for its anti-leukemia properties; its effects on several cell lines were measured and reported in a Table within the study. The chemical activities of garcinoic acid against alpha-glucosidase and alpha-amylase were assessed by conducting the molecular docking study, MM/GBSA calculation, and molecular dynamics (MD) simulation. The anti-cancer activities of this compound were evaluated against some leukemia cancer cells, such as KASUMI-1, HL-60, THP-1, RS4;11, and MOLT-4. The chemical activities of garcinoic acid against some of the expressed surface receptor proteins (CD44 [4PZ3], CD47 [2JJS], folate receptor [4LRH], EGFR [5WB7], and HER2 [1N8Z]) were investigated using computational methods. The active site of the receptors containing the co-crystallized ligand or determined active sites were investigated.  The discoveries illustrated the interaction among atoms. The compound established firm connections with the enzymes and receptors. Garcinoic acid can restrict the functioning of these enzymes and hinder the proliferation of cancerous cells.