Association of Interleukin-17A rs2275913 Polymorphism with Recurrent Miscarriage: A Systematic Review and Meta-Analysis Study
نویسندگان
1 Student Research Committee, Guilan University of Medical Sciences, Rasht, Iran
2 Firoozabadi Clinical Research Development Unit (FACRDU), Iran University of Medical Sciences, Tehran
3 Obstetric and Gynecologist, Yasuj University of Medical Sciences, Yasuj, Iran
4 Department of Clinical Biochemistry, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
5 Department of Obstetrics and Gynecology, Arash Hospital, Tehran University of Medical Sciences, Tehran, Iran
6 Obstetric and Gynecologist, Yasuj University of Medical Sciences, Yasuj, Iran
7 Department of Reproductive Health, School of Nursing and Midwifery, Tehran University of Medical Science, Tehran, Iran
8 Department of Midwifery, Shoushtar Faculty of Medical Sciences, Shoushtar, Iran
doi
10.22074/ijfs.2023.546127.1248چکیده
Recurrent miscarriage (RM) is a condition defined as having three or more consecutive pregnancy losses before the20 weeks of pregnancy. The present study was undertaken to investigate association of Interleukin-17A (IL-17A)rs2275913 polymorphism with RM. To this end, we searched the international databases (Web of Science, PubMed,Embase, and Scopus) and extracted studies investigating the association of IL-17A rs2275913 polymorphism withRM using the appropriate keywords. The collected data were analyzed with the random-effects model and STATA(version 14). A total of five studies met the eligibility criteria, and total sample size was 998 subjects. Mean ageof the cases and controls were 31.41 ± 4.16 and 30.56 ± 3.5 years, respectively. Our results disclosed a significantrelationship of the IL-17A rs2275913 AA genotype [odds ratio (OR)=1.68; 95% confidence interval (CI)=1.16-2.43; I2=19; P=0.294) with RM. There was no statistically significant correlation between IL-17A rs2275913 GGgenotype (OR=1.04; 95% CI=0.64-1.7; I2=59.5; P=0.042) and GA genotype (OR=0.85; 95% CI=0.65-1.12; I2=19.1;P=0.293) with RM. Our findings revealed that the IL-17A rs2275913 polymorphism is associated with RM, and theAA genotype of this polymorphism increased possibility of being involved in RM.
